We aim to be the national and an international leader in genomic medicine to advance research and improve human health

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The Health 2030 Genome Center aims to be the national and international leader in genomic medicine to advance research and improve human health.

Health 2030 genome center

Health 2030 genome center

The Health 2030 Genome Center is a multi-institutional hub established to promote genomic medicine in Switzerland and provide sequencing and analysis services to the research and clinical community. The Genome Center is the genomic medicine arm of the Health 2030 initiative (health2030.ch), whose goal is to promote Swiss personalized medicine (initiated by: EPFL, UNIGE, CHUV, HUG, UNIL, InselSpital, and UNIBE).

The Genome Center is more than simply a large-scale sequencing facility: it aims to integrate and synergize with several groups working on human genetics and genomics in Switzerland.

The Genome Center was conceived as a hub for genetics and genomics research to foster collaboration, increase communication, and promote the sharing of ideas, allowing for the long-term development of major initiatives. In addition, the Genome Center increases the impact of the sequencing facility itself as new developments and projects are discussed and designed in real-time through daily interactions of all stakeholders.

More broadly, the Genome Center aims to advance knowledge of disease pathogenesis, improving human health through preventive, diagnostic and therapeutic approaches, thereby realizing the social and economic benefits of genomics.

The inception of the Health 2030 Genome Center was supported by a private Geneva-based foundation, the Personalized Health and Related Technologies (PHRT) of the ETH Domain and the Health 2030 initiative in personalized health.

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Health 2030 genome center structure

Health 2030 genome center structure
  • A sequencing platform that performs clinical-grade, high-throughput sequencing for research and clinical services,
  • A data analytics platform that develops large-scale data analytics and pipelines for research and clinical use,
  • A research community working at the forefront of genomics, whether in basic science or in the clinics, which serves as the intellectual backbone for the Genome Center strategy and services. In return, the Genome Center fosters synergies within this community.
  • The Genome Center activities are supported by a Strategic Board, Clinical Board, and a Science Council.

TEAM

TEAM
JFellay
Jacques Fellay

Chief Scientific Officer

Jacques Fellay, MD PhD

Jacques Fellay is a medical doctor and researcher, with expertise in genomics and infectious diseases and strong interest in personalized health. He is the founding director of the Precision Medicine Unit of the Lausanne University Hospital (CHUV) and leads a genomics laboratory at the EPFL School of Life Sciences.

The aim of his research is to decipher the genetic basis of inter-individual differences in immunity and responses to infections.
His group explores the role of human genetic variation in the host-pathogen battle, in the hope of shedding new light on basic biological mechanisms, and of paving the way toward more personalized approaches to health.

He received multiple awards, including the National Latsis Prize in 2011 for his work on the genetic control of HIV and hepatitis C virus infections.

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KHarshman
Keith Harshman

Chief Operating Officer

Keith Harshman, PhD

Keith Harshman received a PhD in Biochemistry from the California Institute of Technology in 1990.Following post-doctoral fellowships at the Universityof Zurich and the Sloan-Kettering Cancer Center, in 1993 he joined Myriad Geneticswhere he workedfirst as a Senior Scientist and later as the Director of Central Nervous System Disease Research. In 1997 he moved to the Spanish National Biotechnology Center as the Head of the Functional Genomics Unit. In 2003 he joined the Center for Integrative Genomics at the University of Lausanne where he served as Coordinator of the Genomic Technologies Facility.He moved tothe Health 2030 Genome Center in December of 2017.

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Ioannis Xenarios

Chief Data Officer

Ioannis Xenarios, PhD

Ioannis Xenarios is a trained computational immunologist who received a PhD from the University of Lausanne and the Ludwig Institute for Cancer Research. During his study he taught bioinformatics and computational biology in the early days of bioinformatics to student in biochemistry. At the end of his PhD he moved to UCLA University of California Los Angeles where he worked on several comparative genomics and interactions databases to study complexity of cellular networks. He then moved to Serono (later bought by Merck into Merck-Serono) to lead the development in proteomics and genomics in both translational and early discovery. He then led the group of Vital-IT and Swiss-Prot at the SIB Swiss Institute of Bioinformatics for eleven years where he developed with his team methods in non invasive prenatal diagnostic, early biomarker discovery in diabetes, neo-antigen, systems immunology in cancer biology, integrative biology and proteogenomics approaches.
He is also a professor of computational biology and bioinformatics at the University of Lausanne and a Professeur titulaire at the University of Geneva.

He has now a secondment at the Genome Center to develop and lead the establishment of the Data Analytics and Interpretation Platform.

Ioannis Xenarios served on several national and international body (ESFRI, IMI-JU, FRM and several computational and non-computational journals).

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Petros Tsantoulis

Chief Medical Officer

Petros Tsantoulis, MD, PhD

Petros Tsantoulis obtained his medical degree from the University of Athens, Greece, in 2003. He completed his doctoral thesis in 2007 at the same university under the supervision of Prof Vassilis Gorgoulis studying the genome-wide distribution of double-strand breaks in models of cancer. Petros Tsantoulis came to Geneva to work at the HUG where he was trained as a specialist in both Internal Medicine and Oncology. Since 2011 he has been working in the Department of Medical Oncology, where he co-founded the Molecular Tumorboard in 2016. His research focus is motivated by his interest in precision oncology and involves the development of biomarkers that can inform cancer prognosis and predict response to treatment, and the recognition of clinically meaningful disease subtypes. Petros Tsantoulis maintains a clinical activity focused on urogenital tumors.

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Katrin Männik

Head of Data Strategy

Katrin Männik, PhD

Katrin Männik was trained in biomedicine, molecular diagnostics and gene technology. She received a PhD from the University of Tartu in 2012. Following post-doctoral training at the Center for Integrative Genomics at the University of Lausanne, she worked as a Research Associate at the University of Lausanne and at the Estonian Genome Center (Estonian population-based biobank). She joined the Health 2030 Genome Center in November 2019.

Her research, supported by the European Commission, the Swiss National Science Foundation and the Jacobs Foundation, has been mainly focused on genetic variants underlying neurodevelopmental disorders and variability of complex traits in the population.

She has authored and co-authored numerous studies published in the top scientific and medical journals (e.g. JAMA, Nature, Am J Hum Genet), and presented platform talks in main international scientific conferences in the field of human genetics and personalized medicine.  

Besides basic research she has a longtime interest in translational and ethical aspects related to the usage of genetic data in healthcare. Katrin Männik has been participating in various initiatives aiming to reach out to the medical community and to society. She is actively involved in national and international projects that work towards maximizing the impact of research and setting the ground for the emergence of personalized medicine. 

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Elena Torres

Internal Communications and Administration Manager

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DNA Sequencing Platform Team
Data Analytics and Interpretation Platform Team
Science Council

news & events

news & events
Image: Copyright Julien Gregorio/HUG
07.07.2022

Hunt for the genome of SARS-CoV-2 variants goes on in Switzerland

The Swiss National SARS-CoV-2 Genomic Surveillance Program introduced in May 2021 by the Federal Office of Public...

11.05.2021

The Health 2030 Genome Center Receives ISO 15189 Accreditation

The accreditation granted to the Health 2030 Genome Center is unique among Swiss public institutions in its...

28.04.2021

Data Analysis and Interpretation at the Health 2030 Genome Center: now and beyond

The first session of the Health 2030 Genome Center Webinar Series was held on April 28, 2021....

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